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Hair Regeneration – A Non-Surgical Hair Transplant Alternative

Hair Regeneration is a groundbreaking hair loss treatment developed by Dr. Amiya Prasad. The treatment uses an advanced stem cell-based wound healing technology to reverse hair thinning and kick start the growth cycle of hair.

Before and 6 months after hair regeneration treatment on male patient top of the head view
Before and 6 months after hair regeneration treatment on male patient top of the head view

Two men in their 30s with minimal response to finasteride (Propecia®) were treated with Hair Regeneration show thick hair growth with natural density. No hair transplant surgery was performed

before and 7 months after Hair Regeneration for male pattern hair loss
before and 7 months after Hair Regeneration for male pattern hair loss

What is Hair Regeneration?

Hair Regeneration is composed of:

  • Extracellular matrix (ECM) made by ACell is a wound-healing material first used in the recruitment of adult stem cells to regenerate human tissue like skin and muscle. When used in treating hair loss, ECM stimulates the body’s production of adult stem cells, which appears clinically to stimulate the hair follicle affected by genetic and other causes of hair loss.
  • Platelet-rich plasma (PRP) is the isolated serum obtained from a patient’s own blood which contains concentrated healing and growth factors. PRP is used in regenerative medicine, particularly in orthopedics and oral surgery.
  • Vitamin D is a nutrient which was demonstrated, in a study conducted by the University of Tokyo, to help enhance the viability of hair follicles grown in tissue culture which were then implanted into test subjects.
  • Other natural healing and hair growth factors.

How Hair Regeneration work?

When strategically injected into the scalp, Hair Regeneration appears to reactivate hair that is not growing and improve the quality of existing hair.

Hair Regeneration helps hair that was previously thinning to progressively become thicker and stronger (often comeing back darker). This combination of effect results in improvement in scalp coverage.

microscope image of thinning hair
microscope image of Thicker hair after hair regeneration injection on thinning hair
Thinned hair that almost disappeared comes back thicker after Hair Regeneration. Existing surrounding hair also becomes thicker, adding to volume density of hair.

Does Hair Regeneration Works?

The Hair Regeneration treatment has appeared to be effective in 99% of male and female patients who undergo this treatment. The procedure takes less than 2 hours and appears to be effective for 2 to 5 years, and beyond. Individual results vary based on hair loss profiles determined during consultation.

See patient case studies of Hair Regeneration and Hair Regeneration before and after photos

The Hair Regeneration treatment can be so effective in thickening hair that most people who undergo the treatment don’t feel they need an additional hair transplant. This, however, is dependent on the degree of hair loss they have at the time of their treatment.

Alternative to Hair Transplant Surgery

Understanding that hair transplant surgery is limited by the number of hairs available for grafting, choosing to have hair transplant surgery after this procedure allows for more strategic placement of grafts with more density, since significant scalp coverage has been achieved first with Hair Regeneration.

Before and after non-surgical hair loss treatment - male patient front view
Before and after non-surgical hair loss treatment - male patient front view
before and after hair loss treatment results - male patient right side view
Two young men with with significant thickening of their existing hair and stopped progressive hair loss. Thick, natural-looking hair meant they avoided doing a hair transplant altogether. Both men had minimal response to finasteride (Propecia®) which they were taking prior to the Hair Regeneration treatment.
before and after hair loss treatment results - male patient right side view
Two young men with with significant thickening of their existing hair and stopped progressive hair loss. Thick, natural-looking hair meant they avoided doing a hair transplant altogether. Both men had minimal response to finasteride (Propecia®) which they were taking prior to the Hair Regeneration treatment.

How to Boost Hair Growth After Hair Transplant

Hair Regeneration can also work synergistically to enhance the results of hair transplants which have already been performed.

  1. The combination of the wound-healing materials in Hair Regeneration is used to improve healing of the incisions created by follicular unit transplantation (FUT) or follicular unit extraction (FUE) on the donor area on the back of the head.
  2. Hair Regeneration can prevent progressive, future hair loss — an important issue that hair transplants do not address. It has been shown that a significant percentage of people who undergo hair transplants often need more surgery since they continue to lose hair.
  3. Hair Regeneration’s wound healing components improves the healing of transplanted hair follicles, thereby increasing the survival rate of transplanted hair grafts.

What is Extracellular Matrix?

Extracellular matrix (ECM) or ACellular matrix, produced by the company ACell, is a byproduct of porcine bladder tissue that has proven regenerative properties.

It has multiple 510(k) clearances for use in clinical and therapeutic practices. ACell’s MatriStem™ is the second generation of their core extracellular matrix technology that provides a basement membrane surface that is ideal for epithelial cell growth in various medical applications.

ECM’s regenerative properties has been proven to help in the production of new skin and muscle tissue. The product itself is stripped of all cells, including muscle tissue, to prevent any allergic reactions or rejection when used on humans.

On Acell

Acell vial Extracellular matrix works by recruiting adult stem cells, along with increased blood supply, to the area where the wound is present. It changes inactive adult stem cells naturally present in the body into active progenitor cells to stimulate a healing reaction that duplicates native tissue instead of scar tissue. ECM provides growth factors and proteins needed for tissue generation, and creates a temporary non-crosslinked scaffolding for tissue reconstruction that mimics surrounding healthy yet damaged tissue. This temporary scaffolding slowly releases growth factors until it is metabolized and absorbed by the body, allowing healing and regeneration to be performed by a person’s own cells and tissue. 

Are there any differences between PRP and ACell treatments for hair loss? PRP and ACell injection treatments when performed effectively can significantly increase hair density and coverage in men and women who suffer from genetic pattern hair loss PRP and ACell treatment are often sought out by people who’ve undergone several treatments with PRP or platelet-rich plasma alone without significant benefit after many sessions oftentimes there are improvements seen in hair growth after PRP injection but the growth is typically not sustained beyond the short term in addition a lot of people are looking for an alternative to surgical hair transplantation as well as ways to improve their results after recently having hair transplant surgery with PRP and ACell the key ingredients are spelled out in a generic name and there is often an assumption that the formulation execution results of PRP and ACell treatment are the same between doctors in reality results formulations and treatment protocols are not universal I’ll discuss how PRP and a cell treatments differ amongst doctors and how you can decide which treatment is best suited for your hair loss condition I’m Dr. Amiya Prasad I’m a Board-certified cosmetic surgeon and Fellowship-trained oculofacial plastic and reconstructive surgeon I’ve been in practice in Manhattan and Long Island for over 20 years I’m actually one of the original pioneers of PRP and a self treatment this began when I first used extracellular matrix or ECM by ACell to improve healing when I performed hair transplant surgery the word a cell is actually the name of the company that produces the material called extracellular matrix or ECM extracellular matrix or ECM is an advanced healing material derived from pig bladder although this is stem cell technology this material is not made up of stem cells the extracellular matrix material actually stimulates your body’s own adult stem cells to behave in ways which significantly improves wound healing I became more experienced with this material and its behavior by using it for incisions when I performed facelift surgery and other cosmetic and reconstructive surgical procedures I observed when using this material for hair transplant surgery that not only did the hair grafts heal better but the native thinning hair unexpectedly became thicker the hair thickening effect was observed over one year after surgery I was inspired by this observation to work on developing optimal concentrations of ACell with PRP in addition to delivery methods to potentially create a standalone procedure to help men and women with genetic pattern hair loss without surgery since there was no prior knowledge in this area I spent years developing and refining the process for maximal effectiveness with consistent results and very importantly to achieve the most benefit for the longest period of duration which requires the fewest number of treatments in spite of many years of skepticism and frequent dismissal of the concept from many members of the dermatology Plastic Surgery and hair restoration surgery community the success of our treatment we call TrichoStem Hair Regeneration as a standalone procedure since I started in 2011 could not be ignored and has become so well recognized that patients have been coming to us from around the world for male and female pattern hair loss treatment the improvement in scalp coverage we see is based on the reactivation of hair that is present but not growing as well as thickening of thinning hair our success in changing the way hair loss is treated has resulted in the same doctors who are skeptics about PRP and ASL to now offer their own limited single formulation which requires that their patients come in every month to every three months for scalp injections of PRP or PRP with a self so if you are experiencing hair loss how do you determine first of all if PRP or PRP with a cell is appropriate for you and if it is which method will be most effective for you since the time of initiating my work of PRP and ACell I looked at specific characteristics and every patient I treated and look at how they responded to the treatment dosing and methods which I employed for them I examined every patient and performed microscopic and high-resolution digital photography every three to six months for the duration of five years or more based on these observations I recognized the need to create individualized treatment plants for example a young male with aggressive hair loss needs a treatment strategy which is different from a middle-aged woman with slow progressive hair thinning I see many people who are experiencing hair loss and had gotten treatment in a shotgun approach regardless of their age gender or degree of hair loss unfortunately this makes people being treated for hair loss to be frustrated and feel that this treatment category just doesn’t work in our practice we spend a lot of time looking at our patients we look in depth at medical history as well as hormonal issues medications and other variables to properly diagnose each patient before determining if he or she is a candidate for PRP and ACell or as we refer to our system TrichoStem Hair Regeneration I can attest from experience that one approach to hair loss treatment cannot be applied to every patient after I assess a patient and diagnosed them with androgenetic alopecia or genetic pattern hair loss I provide them a treatment plan for example if you’re a 40 year old male who began to lose hair in your early 30s and you have a moderate to advanced degree of hair loss you might be a candidate for a two-year treatment plan during which you would receive two treatments separated by about 18 months the benefits of two treatments as well as other therapies would likely result in improvement which would be sustained for 3 to 5 years for most female pattern hair loss patients we have also had comparable and often longer lasting results I can say that I’m very happy to see the continued growth and recognition of PRP and ACell as a treatment for hair loss however I must stress that hair loss is progressive and is managed not cured in so many ways I see parallels between the marketing of PRP as well as ACell by doctors with little to no prior hair loss treatment experience with hair loss management such as having performed hair transplant surgery and the aggressive marketing of devices for skin tightening or fat reduction which are being used for people who are not good candidates for these procedures I see this as a part of an overall trend which I refer to as cosmetic medical retailing in cosmetic medical retailing the practitioner is more of a sales person who is not interested in a long-term doctor-patient relationship my role as a doctor is to first diagnose manage and advocate for the patient’s best interest in cosmetic medical retailing the patient is more of an opportunity for a one-off transaction with no concern from the fact in the long-term implications of any treatment they sell even worse it’s common for particularly unethical medical retail practices to steal before-and-after photos we are constantly being informed about practices stealing our photos and misrepresenting these photos as their own I have found that many people who are trying PRP or ACell plus PRP in clinics where treatments are scheduled monthly or multiple times per year find themselves stopping after three to four treatments which is understandable having multiple injections in the scalp every month to every three months can become pretty irritating more importantly the question is why do you need so many injection sessions if you think about it the cost of these injections adds up over time and without any significant long-term benefit these injection treatments become financially and logistically unsustainable essentially set up for failure I can state from having many years of experience with ACell with PRP starting in 2011 that a proper diagnosis with a customized treatment plan limited to no more than two treatment sessions provides an expected average duration of 3 to 5 years this appears to be at this time the most effective strategy which is the basis of our success with TrichoStem Hair Regeneration since 2011 I’ve been helping men and women from around the world with genetic pattern hair loss improve their appearance TrichoStem Hair Regeneration is a system which involves the application of a range of individually customized formulations delivery methods and treatment plans as a growing number of doctors start to offer PRP and a cell the challenge is for patients to be able to make informed decisions about which strategy is suited for their needs I am open with my patients about my knowledge derived from my experience developing our system I’m clear with every patient about the reality that hair loss is genetically hardwired and progressive you should expect during a consultation for the doctor to answer your question directly and honestly be wary of claims that sound too good to be true nor should you get vague answers about what to expect after treatment in my practice I provide every patient with the treatment plan and a clear schedule of treatments needed to achieve improved scalp coverage for what is typically three to five years I hope you found this information helpful thank you for your question

How Does Extracellular Matrix Work for Hair Regeneration?

The complexity of the hair follicle is evident by the limited success pharmaceutical and biotechnology companies have had in creating new solutions for hair loss. The search for “hair cloning” remains unsuccessful.

Dr. Prasad has applied his clinical experience from using extracellular matrix for procedures he performs for cosmetic and reconstructive surgery to develop the formulations and methods of delivery for Hair Regeneration. He believes that hair thinning at the cellular level occurs from interruptions or “injuries” to the hair production process. This concept, combined with his method of controlled stimulation through the wound healing process, has resulted in hair thickening using your body’s internal “intelligence” to “fix what is broken”.

Wound healing concept illustration
WOUND HEALING CONCEPT WHERE INACTIVE ADULT STEM CELLS ARE CATALYZED BY THE HAIR REGENERATION TREATMENT AND TURNED INTO ACTIVE PROGENITOR CELLS. RENEWED ACTIVITY IN AT CELLULAR LEVEL INVIGORATES THE HAIR GROWTH PROCESS FOR THICKER HAIR GROWTH.

The benefits of the Hair Regeneration formulation, along with years of refinement and clinical data, has put Dr. Prasad in a leadership position when it comes to hair loss treatment. His highly effective hair loss treatment works successfully in 99% of male and female patients.

Dr. Prasad’s experience with Acell

Dr. Prasad doing Ear tissue regeneration procedure on a male patient Dr. Amiya Prasad is a pioneer in using extracellular matrix for hair restoration, and is also a renowned facial cosmetic and reconstructive surgeon. He has extensive experience in the clinical and surgical use of ECM in regenerating other areas that need advanced healing and scar reduction. 

In a patient who lost a significant part of his ear due to cancer, Dr. Prasad used ECM in a first-of-its-kind tissue regeneration surgery to reconstruct his ear. While ECM has been used in tissue reconstruction, this was the first time it was used in this type of reconstructive surgery involving skin and cartilage.

As a highly respected Cosmetic Surgeon, Dr. Prasad is known within New York social circles, as well as throughout the world. One thing Dr. Prasad is particularly well-known for is his ability to produce very natural-looking results with facial cosmetic surgery, which includes facelifts. In facelift surgery, facial incisions are necessary as the lifting point of the skin. Dr. Prasad is well-known for having surgical incisions appear unnoticeable, and for clientele who show a more youthful and healthy look without the obvious signs of surgery.

Dr. Prasad uses ECM extensively in facelift surgery for the advanced healing of incisions to prevent scar formation and any noticeable signs of facial cosmetic surgery. Aside from his work with facelifts, Dr. Prasad is also well known for complex eyelid surgery which requires extensive grafting. People with complications from eyelid cosmetic surgery come from around the world to visit his practice and have benefited from his methods of employing extracellular matrix and platelet-rich plasma to restore their appearance.

Facelift incision healing with ECM 1 month after surgery

Patient Reviews on Hair Regeneration

patient review on hair regeneration: 7 months after Hair Regeneration my results are far greater than I could have ever imagined
patient review on hair regeneration: 5 months out my hair is significantly thicker.
i feel much more confident about my hair thanks to Dr. Prasad and his team. Reviewer: Camgreene
patient review: Dr. Prasad is really on the cutting edge on this technology
patient review: Six months post-op, I can feel and see a real change in my hairline
patient review on hair regeneration: am seeing stronger more healthy looking hair
patient review: 10 months after I had the PRP+Acell (hair regeneration) injection, my hair is a lot thicker

What is the best treatment for Hair Loss?

The best treatment for your hair loss depends on the cause of your hair loss. Knowing what causes your hair loss and stage of hair loss is the start. Schedule a consultation with us for full assessment of your case and to determine what is the best solution for your hair loss/hair thinning. You may fill up the form below or call (212) 265-8877 in Manhattan, (516) 742-4636 in Garden City, Long Island, or (703) 356-1336 in Vienna, Virginia location.

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